Deep brain stimulation and medication for parkinsonian tremor during secondary tasks
Identifieur interne : 002F10 ( Main/Exploration ); précédent : 002F09; suivant : 002F11Deep brain stimulation and medication for parkinsonian tremor during secondary tasks
Auteurs : Molly M. Sturman [États-Unis] ; David E. Vaillancourt [États-Unis] ; Leo Verhagen Metman [États-Unis] ; Diane K. Sierens [États-Unis] ; Roy A. E. Bakay [États-Unis] ; Daniel M. Corcos [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2007-06-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Antiparkinson Agents (therapeutic use), Chemotherapy, Cognition Disorders (diagnosis), Cognition Disorders (epidemiology), Combined Modality Therapy, Deep Brain Stimulation (methods), Deep brain stimulation, Electromyography, Female, Forearm, Humans, Male, Muscle, Skeletal (innervation), Nervous system diseases, Parkinson Disease (drug therapy), Parkinson Disease (therapy), Parkinson disease, Parkinson's disease, Subthalamic Nucleus (physiology), Subthalamic nucleus, Tremor, Wrist, deep brain stimulation, secondary task, subthalamic nucleus, tremor.
- MESH :
- chemical , therapeutic use : Antiparkinson Agents.
- diagnosis : Cognition Disorders.
- drug therapy : Parkinson Disease.
- epidemiology : Cognition Disorders.
- innervation : Muscle, Skeletal.
- methods : Deep Brain Stimulation.
- physiology : Subthalamic Nucleus.
- therapy : Parkinson Disease.
- Combined Modality Therapy, Electromyography, Female, Forearm, Humans, Male, Wrist.
Abstract
This study examined the efficacy of subthalamic nucleus (STN), deep brain stimulation (DBS), and medication for resting tremor during performance of secondary tasks. Hand tremor was recorded using accelerometry and electromyography (EMG) from 10 patients with Parkinson's disease (PD) and ten matched control subjects. The PD subjects were examined off treatment, on STN DBS, on medication, and on STN DBS plus medication. In the first experiment, tremor was recorded in a quiet condition and during a cognitive task designed to enhance tremor. In the second experiment, tremor was recorded in a quiet condition and during isometric finger flexion (motor task) with the contralateral limb at 5% of the maximal voluntary contraction (MVC) that was designed to suppress tremor. Results showed that: (1) STN DBS and medication reduced tremor during a cognitive task that exacerbated tremor, (2) STN DBS normalized tremor frequency in both the quiet and cognitive task conditions, whereas tremor amplitude was only normalized in the quiet condition, (3) a secondary motor task reduced tremor in a similar manner to STN DBS. These findings demonstrate that STN DBS still suppresses tremor in the presence of a cognitive task. Furthermore, a secondary motor task of the opposite limb suppresses tremor to levels comparable to STN DBS. © 2007 Movement Disorder Society
Url:
- https://api.istex.fr/document/C778C563BE2DA5C39D8F87F71C5697D6AC60F0BE/fulltext/pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2366974
DOI: 10.1002/mds.21518
Affiliations:
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Le document en format XML
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2007-06-15">2007-06-15</date><biblScope unit="vol">22</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="1157">1157</biblScope><biblScope unit="page" to="1163">1163</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">C778C563BE2DA5C39D8F87F71C5697D6AC60F0BE</idno><idno type="DOI">10.1002/mds.21518</idno><idno type="ArticleID">MDS21518</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antiparkinson Agents (therapeutic use)</term><term>Chemotherapy</term><term>Cognition Disorders (diagnosis)</term><term>Cognition Disorders (epidemiology)</term><term>Combined Modality Therapy</term><term>Deep Brain Stimulation (methods)</term><term>Deep brain stimulation</term><term>Electromyography</term><term>Female</term><term>Forearm</term><term>Humans</term><term>Male</term><term>Muscle, Skeletal (innervation)</term><term>Nervous system diseases</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (therapy)</term><term>Parkinson disease</term><term>Parkinson's disease</term><term>Subthalamic Nucleus (physiology)</term><term>Subthalamic nucleus</term><term>Tremor</term><term>Wrist</term><term>deep brain stimulation</term><term>secondary task</term><term>subthalamic nucleus</term><term>tremor</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Cognition Disorders</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Cognition Disorders</term></keywords><keywords scheme="MESH" qualifier="innervation" xml:lang="en"><term>Muscle, Skeletal</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Deep Brain Stimulation</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Combined Modality Therapy</term><term>Electromyography</term><term>Female</term><term>Forearm</term><term>Humans</term><term>Male</term><term>Wrist</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Chimiothérapie</term><term>Noyau sousthalamique</term><term>Parkinson maladie</term><term>Stimulation cérébrale profonde</term><term>Système nerveux pathologie</term><term>Tremblement</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This study examined the efficacy of subthalamic nucleus (STN), deep brain stimulation (DBS), and medication for resting tremor during performance of secondary tasks. Hand tremor was recorded using accelerometry and electromyography (EMG) from 10 patients with Parkinson's disease (PD) and ten matched control subjects. The PD subjects were examined off treatment, on STN DBS, on medication, and on STN DBS plus medication. In the first experiment, tremor was recorded in a quiet condition and during a cognitive task designed to enhance tremor. In the second experiment, tremor was recorded in a quiet condition and during isometric finger flexion (motor task) with the contralateral limb at 5% of the maximal voluntary contraction (MVC) that was designed to suppress tremor. Results showed that: (1) STN DBS and medication reduced tremor during a cognitive task that exacerbated tremor, (2) STN DBS normalized tremor frequency in both the quiet and cognitive task conditions, whereas tremor amplitude was only normalized in the quiet condition, (3) a secondary motor task reduced tremor in a similar manner to STN DBS. These findings demonstrate that STN DBS still suppresses tremor in the presence of a cognitive task. Furthermore, a secondary motor task of the opposite limb suppresses tremor to levels comparable to STN DBS. © 2007 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Illinois</li></region></list><tree><country name="États-Unis"><region name="Illinois"><name sortKey="Sturman, Molly M" sort="Sturman, Molly M" uniqKey="Sturman M" first="Molly M." last="Sturman">Molly M. Sturman</name></region><name sortKey="Bakay, Roy A E" sort="Bakay, Roy A E" uniqKey="Bakay R" first="Roy A. E." last="Bakay">Roy A. E. Bakay</name><name sortKey="Bakay, Roy A E" sort="Bakay, Roy A E" uniqKey="Bakay R" first="Roy A. E." last="Bakay">Roy A. E. Bakay</name><name sortKey="Corcos, Daniel M" sort="Corcos, Daniel M" uniqKey="Corcos D" first="Daniel M." last="Corcos">Daniel M. Corcos</name><name sortKey="Corcos, Daniel M" sort="Corcos, Daniel M" uniqKey="Corcos D" first="Daniel M." last="Corcos">Daniel M. Corcos</name><name sortKey="Corcos, Daniel M" sort="Corcos, Daniel M" uniqKey="Corcos D" first="Daniel M." last="Corcos">Daniel M. Corcos</name><name sortKey="Corcos, Daniel M" sort="Corcos, Daniel M" uniqKey="Corcos D" first="Daniel M." last="Corcos">Daniel M. Corcos</name><name sortKey="Metman, Leo Verhagen" sort="Metman, Leo Verhagen" uniqKey="Metman L" first="Leo Verhagen" last="Metman">Leo Verhagen Metman</name><name sortKey="Metman, Leo Verhagen" sort="Metman, Leo Verhagen" uniqKey="Metman L" first="Leo Verhagen" last="Metman">Leo Verhagen Metman</name><name sortKey="Sierens, Diane K" sort="Sierens, Diane K" uniqKey="Sierens D" first="Diane K." last="Sierens">Diane K. Sierens</name><name sortKey="Vaillancourt, David E" sort="Vaillancourt, David E" uniqKey="Vaillancourt D" first="David E." last="Vaillancourt">David E. Vaillancourt</name><name sortKey="Vaillancourt, David E" sort="Vaillancourt, David E" uniqKey="Vaillancourt D" first="David E." last="Vaillancourt">David E. Vaillancourt</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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